論文

発表年月 タイトル／共同研究者 掲載誌 巻・号・頁 学術機関等
2025/04 A semi‐automated observation approach to quantify mouse skeletal muscle differentiation using immunohistochemistry
Kenta Shimizu, Yamato Yoshida, Kenshin Iwasa, Yasuyuki Fujii, Ursula M. Jacob, Tilman Fritsch, Ali S. Abdelhameed, Vittorio Calabrese, Naomi Osakabe
Physiological Reports
2025/01 Sensory Characteristics and Impact of Flavanol-Rich Grape and Blueberry Extract on Blood Flow Velocity and Oxidative Stress.
Naomi Osakabe, Toshihiko Shoji, Kurumi Onishi, Chie Hirahata, Kento Hiroki, Taiki Fushimi, Yasuyuki Fujii, Ursula M Jacob, Ali S Abdelhameed, Tilman Fritsch, Rosanna Di Paola, Salvatore Cuzzocrea, Vittorio Calabrese
Journal of dietary supplements 1から 17ページまで
2024/12 An immunohistochemical evaluation of fast twitch muscle formation induced by repeated administration of flavan 3‐ols in mice
Yamato Yoshida, Kenta Shimizu, Hitomi Nakamura, Yasuyuki Fujii, Tilman Fritsch, Ali Abdelhameed, Vittorio Calabrese, Naomi Osakabe
The FASEB Journal
2024/11 Verification of the interaction between human bitter taste receptor T2R46 and polyphenols; Computational chemistry approach
Takafumi Shimizu, Taiki Fushimi, Rio Ohno, Fujii Yasuyuki, Kenta Aso, Ursula M. Jacobs, Osamu Nureki, Yoshitomo Suhara, Vittorio Calabrese, Naomi Osakabe
Current Research in Food Science
2024/08 Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components.
Vittorio Calabrese, Naomi Osakabe, Rosalba Siracusa, Sergio Modafferi, Rosanna Di Paola, Salvatore Cuzzocrea, Ursula M Jacob, Tilman Fritsch, Ali S Abdelhameed, Luay Rashan, Uwe Wenzel, Claudio Franceschi, Edward J Calabrese
Mechanisms of ageing and development 220巻 111960から 111960ページまで
2024/06 Gastrointestinal hormone-mediated beneficial bioactivities of bitter polyphenols
Naomi Osakabe, Makoto Ohmoto, Takafumi Shimizu, Naoki Iida, Taiki Fushimi, Yasuyuki Fujii, Keiko Abe, Vittorio Calabrese
 Food Bioscience 61巻 104550から 104550ページまで Elsevier BV
2024/01 Frankincense: A neuronutrient to approach Parkinson's disease treatment.
Vittorio Calabrese, Naomi Osakabe, Foziya Khan, Uwe Wenzel, Sergio Modafferi, Lidia Nicolosi, Tilman Fritsch, Ursula M Jacob, Ali S Abdelhameed, Luay Rashan
Open medicine (Warsaw, Poland) 19巻 1号 20240988から 20240988ページまで
2024/01 Investigating hormesis, aging, and neurodegeneration: From bench to clinics.
Vittorio Calabrese, Uwe Wenzel, Tommaso Piccoli, Ursula M Jacob, Lidia Nicolosi, Giovanni Fazzolari, Gabriella Failla, Tilman Fritsch, Naomi Osakabe, Edward J Calabrese
Open medicine (Warsaw, Poland) 19巻 1号 20240986から 20240986ページまで
2023/11 Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics.
Naomi Osakabe, Sergio Modafferi, Maria Laura Ontario, Francesco Rampulla, Vincenzo Zimbone, Maria Rita Migliore, Tilman Fritsch, Ali S Abdelhameed, Luigi Maiolino, Gabriella Lupo, Carmelina Daniela Anfuso, Elisabetta Genovese, Daniele Monzani, Uwe Wenzel, Edward J Calabrese, R Martin Vabulas, Vittorio Calabrese
Medicina (Kaunas, Lithuania) 59巻 11号
2023/11 Exploring Novel Vitamin K Derivatives with Anti-SARS-CoV-2 Activity.
Taiki Homma, Mika Okamoto, Ryohto Koharazawa, Mayu Hayakawa, Taiki Fushimi, Chisato Tode, Yoshihisa Hirota, Naomi Osakabe, Masanori Baba, Yoshitomo Suhara
ACS omega 8巻 45号 42248から 42263ページまで
2023/11 Procyanidins and sensory nutrition; Do procyanidins modulate homeostasis via astringent taste receptors?
Naomi Osakabe, Taiki Fushimi, Yasuyuki Fujii, Vittorio Calabrese
 Bioscience, biotechnology, and biochemistry 88巻 4号 361から 367ページまで
2023/11 Hormesis defines the limits of lifespan.
Edward J Calabrese, Naomi Osakabe, Rosanna Di Paola, Rosalba Siracusa, Roberta Fusco, Ramona D'Amico, Daniela Impellizzeri, Salvatore Cuzzocrea, Tilman Fritsch, Ali S Abdelhameed, Uwe Wenzel, Claudio Franceschi, Vittorio Calabrese
Ageing research reviews 91巻 102074から 102074ページまで
2023/09 Cinnamtannin A2, (-)-epicatechin tetramer, attenuates skeletal muscle wasting in disuse atrophy model mice induced by hindlimb suspension.
Orie Muta, Shiori Oyama, Minayu Odaka, Kenta Shimizu, Sae Katsuragawa, Kenta Suzuki, Taiki Fushimi, Yasuyuki Fujii, Ryota Akagi, Naomi Osakabe
Journal of clinical biochemistry and nutrition 73巻 2号 124から 130ページまで The Society for Free Radical Research Japan
2023/08 Activation of transient receptor potential channels is involved in reactive oxygen species (ROS)-dependent regulation of blood flow by (-)-epicatechin tetramer cinnamtannin A2.
Taiki Fushimi, Chie Hirahata, Kento Hiroki, Yasuyuki Fujii, Vittorio Calabrese, Yoshitomo Suhara, Naomi Osakabe
 Biochemical pharmacology 214巻 115682から 115682ページまで
2023/05 Difference in endocrine and behavior between short-term single- and paired-housing mice in metabolic cage.
Orie Muta, Minayu Odaka, Yasuyuki Fujii, Taiki Fushimi, Hiroki Sato, Naomi Osakabe
 Neuroscience letters 806巻 137246から 137246ページまで
2023/05 【脳腸相関UPDATE-疾患の予防と健康長寿のための食・栄養・腸環境】(Part3)脳腸相関と食・栄養 ポリフェノール
越阪部 奈緒美
 臨床栄養 142巻 6号 932から 942ページまで 医歯薬出版(株)
2023/03 ポリフェノールと感覚栄養学
越阪部 奈緒美
 日本栄養・食糧学会大会講演要旨集 77回巻 300号 122から 122ページまで (公社)日本栄養・食糧学会
2023/03 Impact of cyanidin 3-O-glucoside on rat micro-and systemic circulation, possibly thorough angiogenesis.
Taiki Fushimi, Shiori Oyama, Ryo Koizumi, Yasuyuki Fujii, Naomi Osakabe
 Journal of clinical biochemistry and nutrition 72巻 2号 132から 138ページまで
2023/03 緑茶カテキンの計算科学的手法を用いたRedox特性の検証
伏見 太希, 平畠 千会, 廣木 健登, 新村 大地, 小林 育朗, 藤井 靖之, 越阪部 奈緒美
 日本栄養・食糧学会大会講演要旨集 77回巻 209から 209ページまで (公社)日本栄養・食糧学会
2023/01 The hemodynamics effect of single or repeated doses of cyanidin-3-glucoside
Naomi Osakabe
 Annals of Nutrition and Metabolism
2023/01 Arousal inducing ability of procyanidin and caffeine, the difference to the mechanism of action
Naomi Osakabe
 Annals of Nutrition and Metabolism
2023/01 Impact of short-term isolation stress on urinary stress hormone excretion
Naomi Osakabe
 Annals of Nutrition and Metabolism
2022/09 Can a Short-term Daily Oral Administration of Propolis Improve Muscle Fatigue and Recovery?
Yuma Tsuchiya, Naoya Hirata, Takashi Asama, Naomi Osakabe, Kosuke Hirata, Ryota Akagi
 International journal of sports medicine 43巻 10号 859から 864ページまで Georg Thieme Verlag KG
2022/01 Hormetic response to B-type procyanidin ingestion involves stress-related neuromodulation via the gut-brain axis: Preclinical and clinical observations.
Naomi Osakabe, Taiki Fushimi, Yasuyuki Fujii
 Frontiers in nutrition 9巻 969823から 969823ページまで
2021/12 Impact of short-term oral dose of cinnamtannin A2, an (-)-epicatechin tetramer, on spatial memory and adult hippocampal neurogenesis in mouse.
Yasuyuki Fujii, Jun Sakata, Fumitaka Sato, Kurumi Onishi, Yuki Yamato, Kazuki Sakata, Shu Taira, Hiroki Sato, Naomi Osakabe
 Biochemical and biophysical research communications 585巻 1から 7ページまで
2021/11 Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation.
Yuko Ishii, Orie Muta, Tomohiro Teshima, Nayuta Hirasima, Minayu Odaka, Taiki Fushimi, Yasuyuki Fujii, Naomi Osakabe
 Nutrients 13巻 12号
2021/11 Evaluation of Polyphenolic Content and Potential Antioxidant Activity of Japanese Cultivars of Peaches, Prunes, and Plums Based on Reversed- and Normal-Phase HPLC and Principal Component Analyses
Naomi Osakabe
 ACS Food Science & Technology American Chemical Society ({ACS})
2021/08 Method for detecting hemodynamic alterations following a single gavage in rats.
Taiki Fushimi, Yasuyuki Fujii, Hideaki Koshino, Kodai Inagawa, Akiko Saito, Ryo Koizumi, Masahiro Shibata, Naomi Osakabe
 Experimental animals 70巻 3号 372から 377ページまで
2021/08 【健康食品・サプリメントを知る】実際の健康食品・サプリメント ポリフェノール
伏見 太希, 藤井 靖之, 越阪部 奈緒美
 診断と治療 109巻 8号 1085から 1090ページまで (株)診断と治療社
2021/05 Theaflavins decrease skeletal muscle wasting in disuse atrophy induced by hindlimb suspension in mice.
Kenta Suzuki, Nayuta Hirashima, Yasuyuki Fujii, Taiki Fushimi, Ayaka Yamamoto, Tomoya Ueno, Ryota Akagi, Naomi Osakabe
 Journal of clinical biochemistry and nutrition 68巻 3号 228から 234ページまで
2021/05 Relationship between hemodynamic alteration and sympathetic nerve activation following a single oral dose of cinnamtannin A2.
Ryo Koizumi, Taiki Fushimi, Yuki Sato, Yasuyuki Fujii, Hiroki Sato, Naomi Osakabe
 Free radical research 55巻 5号 491から 498ページまで Informa {UK} Limited
2021/02 Electrochemical Analysis of Coffee Extractions at Different Roasting Levels Using a Carbon Nanotube Electrode.
Ryotaro Wada, Shota Takahashi, Hitoshi Muguruma, Naomi Osakabe
 Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 37巻 2号 377から 380ページまで JAPAN SOC ANALYTICAL CHEMISTRY
2020/11 Effects of Cocoa Polyphenols and Dark Chocolate on Obese Adults: A Scoping Review.
Hasmiza Halib, Amin Ismail, Barakatun-Nisak Mohd Yusof, Naomi Osakabe, Zulfitri Azuan Mat Daud
 Nutrients 12巻 12号 1から 19ページまで
2020/11 Elucidation of the Interaction Between Flavan-3-ols and Protein in Digestive Fluid and its Effect on in Vitro Neurotoxicity
Fujii Yasuyuki, Yoshitomo Suhara, Yusuke Sukikara, Tomohiro Teshima, Yoshihisa Hirota, Kenjiro Yoshimura, Naomi Osakabe
 FREE RADICAL BIOLOGY AND MEDICINE 159巻 ELSEVIER SCIENCE INC
2020/09 Electrochemical Detection of Curcumin in Food with a Carbon Nanotube-Carboxymethylcellulose Electrode.
Ryotaro Wada, Shota Takahashi, Hitoshi Muguruma, Naomi Osakabe
 Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 36巻 9号 1113から 1118ページまで JAPAN SOC ANALYTICAL CHEMISTRY
2020/04 Study on structure-activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity.
Hiroshi Yoshimura, Yoshihisa Hirota, Seiya Soda, Mayu Okazeri, Yuta Takagi, Atsuko Takeuchi, Chisato Tode, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara
Bioorganic & medicinal chemistry letters 30巻 8号 127059から 127059ページまで
2020/04 Dual real-time in？vivo monitoring system of the brain-gut axis.
Yuya Nishimura, Yota Fukuda, Toya Okonogi, Soichiro Yoshikawa, Hajime Karasuyama, Naomi Osakabe, Yuji Ikegaya, Takuya Sasaki, Takahiro Adachi
Biochemical and biophysical research communications 524巻 2号 340から 345ページまで
2020/04 Analysis of Chlorogenic Acids in Coffee with a Multi-walled Carbon Nanotube Electrode
Shota Takahashi, Ryotaro Wada, Hitoshi Muguruma, Naomi Osakabe
 FOOD ANALYTICAL METHODS 13巻 4号 923から 932ページまで SPRINGER
2020/03 Selective detection of rutin in the presence of ascorbic acid with a carbon nanotube electrode
Shota Takahashi, Hitoshi Muguruma, Naomi Osakabe, Hitoshi Inoue, Tatsuya Ohsawa
 JAPANESE JOURNAL OF APPLIED PHYSICS 59巻 SD号 IOP PUBLISHING LTD
2020/01 B-type Procyanidins Affect on Blood Flow and NO Production Through the Sympathetic Nervous System
Naomi Osakabe
 Free Radical Biology and Medicine
2020/01 Visualization of mechanical stress-mediated Ca2+ signaling in the gut using intravital imaging.
Yoshiko Aihara, Yota Fukuda, Akiyoshi Takizawa, Naomi Osakabe, Tomomi Aida, Kohichi Tanaka, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi
Bioscience of microbiota, food and health 39巻 4号 209から 218ページまで BMFH Press
2019/12 Electrochemical determination with a long-length carbon nanotube electrode of quercetin glucosides in onion, apple peel, and tartary buckwheat.
Shota Takahashi, Hitoshi Muguruma, Naomi Osakabe, Hitoshi Inoue, Tatsuya Ohsawa
 Food chemistry 300巻 125189から 125189ページまで Elsevier {BV}
2019/11 Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives.
Tatsuma Nishioka, Kaori Endo-Umeda, Yuki Ito, Akane Shimoda, Atsuko Takeuchi, Chisato Tode, Yoshihisa Hirota, Naomi Osakabe, Makoto Makishima, Yoshitomo Suhara
Molecules (Basel, Switzerland) 24巻 23号
2019/10 Elucidation of the Interaction between Flavan-3-ols and Bovine Serum Albumin and Its Effect on Their In-Vitro Cytotoxicity.
Yasuyuki Fujii, Yoshitomo Suhara, Yusuke Sukikara, Tomohiro Teshima, Yoshihisa Hirota, Kenjiro Yoshimura, Naomi Osakabe
 Molecules (Basel, Switzerland) 24巻 20号
2019/07 Corticotropin-releasing hormone is significantly upregulated in the mouse paraventricular nucleus following a single oral dose of cinnamtannin A2 as an (-)-epicatechin tetramer.
Yasuyuki Fujii, Kenta Suzuki, Takahiro Adachi, Shu Taira, Naomi Osakabe
 Journal of clinical biochemistry and nutrition 65巻 1号 29から 33ページまで
2019/05 Polyphenol Analysis in Black Tea with a Carbon Nanotube Electrode.
Satoshi Murakami, Shota Takahashi, Hitoshi Muguruma, Naomi Osakabe, Hitoshi Inoue, Tatsuya Ohsawa
 Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 35巻 5号 529から 534ページまで
2019/03 Acylated anthocyanins derived from purple carrot (Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole
Ayaka Tsutsumi, Yukari Horikoshi, Taiki Fushimi, Akiko Saito, Ryo Koizumi, Yasuyuki Fujii, Qing Qiang Hu, Yoshihisa Hirota, Koichi Aizawa, Naomi Osakabe
Food & Function 10巻 3号 1726から 1735ページまで Royal Society of Chemistry ({RSC})
2019/01 Separationless and Adsorptionless Quantification of Individual Catechins in Green Tea with a Carbon Nanotube-Carboxymethylcellulose Electrode.
Hitoshi Muguruma, Satoshi Murakami, Shota Takahashi, Naomi Osakabe, Hitoshi Inoue, Tatsuya Ohsawa
 Journal of agricultural and food chemistry 67巻 3号 943から 954ページまで
2019/01 Simultaneous Electrochemical Determination of Isoquercitrin and Epigallocatechingallate at a Carbon Nanotube Electrode
Shota Takahashi, Hitoshi Muguruma, Naomi Osakabe, Hitoshi Inoue, Tatsuya Ohsawa
 ELECTROCHEMISTRY 87巻 4号 242から 244ページまで ELECTROCHEMICAL SOC JAPAN
2018/08 Single oral administration of flavan 3-ols induces stress responses monitored with stress hormone elevations in the plasma and paraventricular nucleus.
Yasuyuki Fujii, Kenta Suzuki, Yahiro Hasegawa, Fumio Nanba, Toshiya Toda, Takahiro Adachi, Shu Taira, Naomi Osakabe
 Neuroscience letters 682巻 106から 111ページまで
2018/08 Anthocyanin in purple carrot (Daucus carota L.): Their structures and effect for blood flow
Ayaka Tsutsumi, Yukari Horikoshi, Akiko Saito, Ryo Koizumi, Qing Qiang Hu, Aizawa Koichi, Naomi Osakabe
 ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256巻 AMER CHEMICAL SOC
2018/08 Interaction between brain activation and peripheral physiological alteration following ingestion of flavan 3-ols
Naomi Osakabe
 ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256巻 AMER CHEMICAL SOC
2018/06 Green tea extract and black tea extract differentially influence cecal levels of short-chain fatty acids in rats.
Tomonori Unno, Naomi Osakabe
 Food science & nutrition 6巻 4号 728から 735ページまで WILEY
2018/03 Possible mechanisms of postprandial physiological alterations following flavan 3-ol ingestion.
Naomi Osakabe, Junji Terao
 Nutrition reviews 76巻 3号 174から 186ページまで
2018/01 Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice.
Yuta Nakagawa, Kana Ishimura, Satomi Oya, Masaki Kamino, Yasuyuki Fujii, Fumio Nanba, Toshiya Toda, Takeshi Ishii, Takahiro Adachi, Yoshitomo Suhara, Naomi Osakabe
PloS one 13巻 7号
2018/01 Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.
Yoshihisa Hirota, Kimie Nakagawa, Keigo Isomoto, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara, Toshio Okano
PloS one 13巻 10号
2018/01 Stress response in hypothalamic paraventricular nucleus (PVN) after a single dose of procyanidin supplementation
Naomi Osakabe
 Abstracts of Papers of the American Chemical Society
2017/11 Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice.
Mao Ito, Naoto Kudo, Yuji Miyake, Tatsuya Imai, Tomoki Unno, Yoko Yamashita, Yoshihisa Hirota, Hitoshi Ashida, Naomi Osakabe
 Experimental gerontology 98巻 120から 123ページまで
2017/07 25-hydroxyvitamin D3 may Function via Genomic and Non-Genomic actions
Hirota Y, Suhara Y, Osakabe N, Sakaki T, Okano T
 Anatomy & Physiology: Current Research 7巻 4号 278から 280ページまで
2017/03 Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells.
Kimito Kimura, Yoshihisa Hirota, Shigefumi Kuwahara, Atsuko Takeuchi, Chisato Tode, Akimori Wada, Naomi Osakabe, Yoshitomo Suhara
Journal of medicinal chemistry 60巻 6号 2591から 2596ページまで
2017/02 Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin.
Masaki Ikeda, Manabu Ueda-Wakagi, Kaori Hayashibara, Rei Kitano, Masaya Kawase, Kunihiro Kaihatsu, Nobuo Kato, Yoshitomo Suhara, Naomi Osakabe, Hitoshi Ashida
Molecules (Basel, Switzerland) 22巻 2号 MDPI AG
2016/11 Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1 -deficient mice
Yoshiro Ishimaru, Shota Ushiama, Masataka Narukawa, Misako Yoshioka, Chisayo Kozuka, Naoki Watanabe, Makoto Tsunoda, Naomi Osakabe, Tomiko Asakura, Hiroaki Masuzaki, Keiko Abe
CHEMICAL SENSES 41巻 9号 OXFORD UNIV PRESS
2016/10 Onset of a hypotensive effect following ingestion of flavan 3-ols involved in the activation of adrenergic receptors.
Akiko Saito, Kodai Inagawa, Rikihiko Ebe, Shinobu Fukase, Yukari Horikoshi, Masahiro Shibata, Naomi Osakabe
 Free radical biology & medicine 99巻 584から 592ページまで ELSEVIER SCIENCE INC
2016/06 Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice.
Shota Ushiama, Yoshiro Ishimaru, Masataka Narukawa, Misako Yoshioka, Chisayo Kozuka, Naoki Watanabe, Makoto Tsunoda, Naomi Osakabe, Tomiko Asakura, Hiroaki Masuzaki, Keiko Abe
EBioMedicine 8巻 60から 71ページまで ELSEVIER SCIENCE BV
2016/06 The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials.
Akiko Saito, Risa Nakazato, Yoshitomo Suhara, Masahiro Shibata, Toshiki Fukui, Takeshi Ishii, Toshimichi Asanuma, Kazuo Mochizuki, Tsutomu Nakayama, Naomi Osakabe
The Journal of nutritional biochemistry 32巻 107から 14ページまで ELSEVIER SCIENCE INC
2016/02 A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice.
Naoya Kamio, Takuma Suzuki, Yuto Watanabe, Yoshitomo Suhara, Naomi Osakabe
 Free radical biology & medicine 91巻 256から 63ページまで ELSEVIER SCIENCE INC
2016/01 Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo.
Takahiro Adachi, Shigeru Kakuta, Yoshiko Aihara, Tomonori Kamiya, Yohei Watanabe, Naomi Osakabe, Naoki Hazato, Atsushi Miyawaki, Soichiro Yoshikawa, Takako Usami, Hajime Karasuyama, Hiromi Kimoto-Nira, Kazuhiro Hirayama, Noriko M Tsuji
Frontiers in immunology 7巻 601から 601ページまで FRONTIERS MEDIA SA
2015/01 A Single Oral Administration of Theaflavins Increases Energy Expenditure and the Expression of Metabolic Genes.
Naoto Kudo, Yasunori Arai, Yoshitomo Suhara, Takeshi Ishii, Tsutomu Nakayama, Naomi Osakabe
 PloS one 10巻 9号
2014/09 The flavan-3-ol fraction of cocoa powder suppressed changes associated with early-stage metabolic syndrome in high-fat diet-fed rats.
Naomi Osakabe, Junpei Hoshi, Naoto Kudo, Masahiro Shibata
 Life sciences 114巻 1号 51から 6ページまで PERGAMON-ELSEVIER SCIENCE LTD
2014/09 Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats
Nozomi Aruga, Megumi Toriigahara, Masahiro Shibata, Takeshi Ishii, Tsutomu Nakayama, Naomi Osakabe
 JOURNAL OF FUNCTIONAL FOODS 10巻 355から 363ページまで ELSEVIER SCIENCE BV
2014/04 Flavan-3-ol fraction from cocoa powder promotes mitochondrial biogenesis in skeletal muscle in mice.
Naoki Watanabe, Kodai Inagawa, Masahiro Shibata, Naomi Osakabe
 Lipids in health and disease 13巻 64から 64ページまで BIOMED CENTRAL LTD
2014/01 Alteration of the systemic and microcirculation by a single oral dose of flavan-3-ols.
Kodai Ingawa, Nozomi Aruga, Yusuke Matsumura, Masahiro Shibata, Naomi Osakabe
 PloS one 9巻 4号 PUBLIC LIBRARY SCIENCE
2014/01 Enhancement of energy expenditure following a single oral dose of flavan-3-ols associated with an increase in catecholamine secretion.
Yusuke Matsumura, Yuta Nakagawa, Katsuyuki Mikome, Hiroki Yamamoto, Naomi Osakabe
 PloS one 9巻 11号 PUBLIC LIBRARY SCIENCE
2013/11 Cacao Polyphenols Influence the Regulation of Apolipoproteins
Naomi Osakabe
 Polyphenols in Human Health and Disease 2巻 963から 970ページまで Elsevier Inc.
2013/05 Flavan 3-ols improve metabolic syndrome risk factors: evidence and mechanisms.
Naomi Osakabe
 Journal of clinical biochemistry and nutrition 52巻 3号 186から 92ページまで
2012/12 Ingestion of cocoa ameliorates endothelial dysfunction in mesentery arterioles induced by high fat diet in rats: an in vivo intravital microscopy study.
Naomi Osakabe, Masahiro Shibata
 Life sciences 91巻 23-24号 1196から 200ページまで
2012/04 Polyphenols in Theobroma Cacao Ameliorate Microcirculation: In vivo Intravital Microscopic Observation in Rats
Naomi Osakabe
 JOURNAL OF FOOD AND DRUG ANALYSIS 20巻 288から 291ページまで BUREAU FOOD DRUG ANALYSIS
2011/02 Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.
Akiko Yasuda, Midori Natsume, Naomi Osakabe, Keiko Kawahata, Jinichiro Koga
 Journal of agricultural and food chemistry 59巻 4号 1470から 6ページまで AMER CHEMICAL SOC
2009/09 Procyanidins in Theobroma cacao Reduce Plasma Cholesterol Levels in High Cholesterol-Fed Rats.
Naomi Osakabe, Megumi Yamagishi
 Journal of clinical biochemistry and nutrition 45巻 2号 131から 6ページまで
2008/12 Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolaemic rabbits.
Megumi Akita, Masayoshi Kuwahara, Fumi Itoh, Yoshihisa Nakano, Naomi Osakabe, Tohru Kurosawa, Hirokazu Tsubone
 Basic & clinical pharmacology & toxicology 103巻 6号 581から 7ページまで
2008/11 Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice.
Rie Mukai, Itsuko Fukuda, Shin Nishiumi, Midori Natsume, Naomi Osakabe, Ken-ichi Yoshida, Hitoshi Ashida
 Journal of agricultural and food chemistry 56巻 21号 10399から 405ページまで
2008/01 Inhibitory Effects of Conjugated Epicatechin Metabolites on Peroxynitrite-mediated Nitrotyrosine Formation.
Midori Natsume, Naomi Osakabe, Akiko Yasuda, Toshihiko Osawa, Junji Terao
 Journal of clinical biochemistry and nutrition 42巻 1号 50から 3ページまで
2007/08 Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal Dopaminergic neurons in a rat model of Parkinson's Disease
Krishna P. Datla, Virginia Zbarsky, Deepal Rai, Shabnam Parkar, Naomi Osakabe, Okezie I. Aruoma, David T. Dexter
 JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION 26巻 4号 341から 349ページまで AMER COLLEGE NUTRITION
2007/06 Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder.
Seigo Baba, Midori Natsume, Akiko Yasuda, Yuko Nakamura, Takaaki Tamura, Naomi Osakabe, Minoru Kanegae, Kazuo Kondo
 The Journal of nutrition 137巻 6号 1436から 41ページまで
2007/04 Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice.
Makoto Tomaru, Hirohisa Takano, Naomi Osakabe, Akiko Yasuda, Ken-ichiro Inoue, Rie Yanagisawa, Tsuneto Ohwatari, Hiroshi Uematsu
 Nutrition (Burbank, Los Angeles County, Calif.) 23巻 4号 351から 5ページまで ELSEVIER SCIENCE INC
2007/03 Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.
Seigo Baba, Naomi Osakabe, Yoji Kato, Midori Natsume, Akiko Yasuda, Toshimi Kido, Kumiko Fukuda, Yuko Muto, Kazuo Kondo
 The American journal of clinical nutrition 85巻 3号 709から 17ページまで
2007/01 Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice.
Makoto Tomaru, Hirohisa Takano, Ken-Ichiro Inoue, Rie Yanagisawa, Naomi Osakabe, Akiko Yasuda, Akinori Shimada, Yoji Kato, Hiroshi Uematsu
International journal of molecular medicine 19巻 1号 17から 22ページまで SPANDIDOS PUBL LTD
2006/04 Determination of rosmarinic acid and luteolin in Perilla frutescens Britton (Labiatae)
M Natsume, Y Muto, K Fukuda, T Tokunaga, N Osakabe
 JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 86巻 6号 897から 901ページまで WILEY-BLACKWELL
2005/04 Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits
T Kurosawa, F Itoh, A Nozaki, Y Nakano, S Katsuda, N Osakabe, H Tsubone, K Kondo, H Itakura
 ATHEROSCLEROSIS 179巻 2号 237から 246ページまで ELSEVIER SCI IRELAND LTD
2005/02 Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans
S Baba, N Osakabe, M Natsume, A Yasuda, Y Muto, K Hiyoshi, H Takano, T Yoshikawa, J Terao
 EUROPEAN JOURNAL OF NUTRITION 44巻 1号 1から 9ページまで DR DIETRICH STEINKOPFF VERLAG
2005/02 Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits
T Kurosawa, F Itoh, A Nozaki, Y Nakano, SI Katsuda, N Osakabe, H Tsubone, K Kondo, H Itakura
 JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 12巻 1号 20から 28ページまで JAPAN ATHEROSCLEROSIS SOC
2005/01 Cacao polyphenols and atherosclerosis
Naomi Osakabe
 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 37巻 3号 67から 72ページまで JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
2004/12 In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma
M Natsume, N Osakabe, A Yasuda, S Baba, T Tokunaga, K Kondo, T Osawa, J Terao
 FREE RADICAL RESEARCH 38巻 12号 1341から 1348ページまで TAYLOR & FRANCIS LTD
2004/12 Dose-response study of daily cocoa intake on the oxadative susceptibility of low-density lipoprotein in healthy human volunteers
N Osakabe, S Baba, A Yasuda, T Iwamoto, M Kamiyama, T Tokunaga, K Kondo
 JOURNAL OF HEALTH SCIENCE 50巻 6号 679から 684ページまで PHARMACEUTICAL SOC JAPAN
2004/06 Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model
C Sanbongi, H Takano, N Osakabe, N Sasa, M Natsume, R Yanagisawa, K Inoue, K Sadakane, T Ichinose, T Yoshikawa
 CLINICAL AND EXPERIMENTAL ALLERGY 34巻 6号 971から 977ページまで BLACKWELL PUBLISHING LTD
2004/05 Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid
S Baba, N Osakabe, M Natsume, J Terao
 LIFE SCIENCES 75巻 2号 165から 178ページまで PERGAMON-ELSEVIER SCIENCE LTD
2004/04 Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
N Osakabe, A Yasuda, M Natsume, T Yoshikawa
 CARCINOGENESIS 25巻 4号 549から 557ページまで OXFORD UNIV PRESS
2004/03 Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans
H Takano, N Osakabe, C Sanbongi, R Yanagisawa, K Inoue, A Yasuda, M Natsume, S Baba, E Ichiishi, T Yoshikawa
 EXPERIMENTAL BIOLOGY AND MEDICINE 229巻 3号 247から 254ページまで SOC EXPERIMENTAL BIOLOGY MEDICINE
2004/01 Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats
N Osakabe, M Yamagishi, M Natsume, A Yasuda, T Osawa
 EXPERIMENTAL BIOLOGY AND MEDICINE 229巻 1号 33から 39ページまで SOC EXPERIMENTAL BIOLOGY MEDICINE
2004/01 Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism
N Osakabe, H Takano, C Sanbongi, A Yasuda, R Yanagisawa, K Inoue, T Yoshikawa
 BIOFACTORS 21巻 1-4号 127から 131ページまで IOS PRESS
2003/04 Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: Differences between human and rat
M Natsume, N Osakabe, M Oyama, M Sasaki, S Baba, Y Nakamura, T Osawa, J Terao
 FREE RADICAL BIOLOGY AND MEDICINE 34巻 7号 840から 849ページまで PERGAMON-ELSEVIER SCIENCE LTD
2003/04 Rosmarinic acid inhibits lung injury induced by diesel exhaust particles
C Sanbonoi, H Takano, N Osakabe, N Sasa, M Natsume, R Yanagisawa, K Inoue, Y Kato, TS Osawa, T Yoshikawa
 FREE RADICAL BIOLOGY AND MEDICINE 34巻 8号 1060から 1069ページまで PERGAMON-ELSEVIER SCIENCE LTD
2003/02 Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model
M Yamagishi, M Natsume, N Osakabe, K Okazaki, F Furukawa, T Imazawa, A Nishikawa, M Hirose
 CANCER LETTERS 191巻 1号 49から 57ページまで ELSEVIER SCI IRELAND LTD
2002/11 Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats
M Yamagishi, M Natsume, N Osakabe, H Nakamura, F Furukawa, T Imazawa, A Nishikawa, M Hirose
 CANCER LETTERS 185巻 2号 123から 130ページまで ELSEVIER IRELAND LTD
2002/09 Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-Galactosamine (D-GalN)-sensitized mice
N Osakabe, A Yasuda, M Natsume, C Sanbongi, Y Kato, T Osawa, T Yoshikawa
 FREE RADICAL BIOLOGY AND MEDICINE 33巻 6号 798から 806ページまで PERGAMON-ELSEVIER SCIENCE LTD
2002/07 Absorption and urinary excretion of procyanidin B2 [epicatechin-(4 beta-8)-epicatechin] in rats
S Baba, N Osakabe, M Natsume, J Terao
 FREE RADICAL BIOLOGY AND MEDICINE 33巻 1号 142から 148ページまで PERGAMON-ELSEVIER SCIENCE LTD
2002/04 Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects
T Hatano, H Miyatake, M Natsume, N Osakabe, T Takizawa, H Ito, T Yoshida
 PHYTOCHEMISTRY 59巻 7号 749から 758ページまで PERGAMON-ELSEVIER SCIENCE LTD
2002/01 Catechins and their oligomers linked by C4 → C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro
Naomi Osakabe, Akiko Yasuda, Midori Natsume, Toshio Takizawa, Junji Terao, Kazuo Kondo
 Experimental Biology and Medicine 227巻 1号 51から 56ページまで
2002/01 Catechins and their oligomers linked by C4 -> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro
N Osakabe, A Yasuda, M Natsume, T Takizawa, J Terao, K Kondo
 EXPERIMENTAL BIOLOGY AND MEDICINE 227巻 1号 51から 56ページまで SOC EXPERIMENTAL BIOLOGY MEDICINE
2001/12 Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats
S Baba, N Osakabe, M Natsume, Y Muto, T Takizawa, J Terao
 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 49巻 12号 6050から 6056ページまで AMER CHEMICAL SOC
2001/11 In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats
S Baba, N Osakabe, M Natsume, Y Muto, T Takizawa, J Terao
 JOURNAL OF NUTRITION 131巻 11号 2885から 2891ページまで AMER INST NUTRITION
2001/01 The inhibitory effect of cacao liquor crude polyphenols (CLP) on experimental arteriosclerosis with calcification in rat soft tissue
Masako Horiuchi, Naomi Osakabe, Toshio Takizawa, Yoshiyuki Seyama
 Journal of Health Science 47巻 2号 208から 212ページまで
2001/01 Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers
N Osakabe, S Baba, A Yasuda, T Iwamoto, M Kamiyama, T Takizawa, H Itakura, K Kondo
 FREE RADICAL RESEARCH 34巻 1号 93から 99ページまで HARWOOD ACAD PUBL GMBH
2000/11 Cocoa powder enhances the level of antioxidative activity in rat plasma
S Baba, N Osakabe, M Natsume, A Yasuda, T Takizawa, T Nakamura, J Terao
 BRITISH JOURNAL OF NUTRITION 84巻 5号 673から 680ページまで C A B INTERNATIONAL
2000/08 Antioxidant effects of polyphenols in chocolate on low-density lipoprotein both in vitro and ex vivo
R Hirano, N Osakabe, T Iwamoto, A Matsumoto, M Natsume, T Takizawa, O Igarashi, H Itakura, K Kondo
 JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 46巻 4号 199から 204ページまで CENTER ACADEMIC PUBL JAPAN
2000/01 Antioxidative polyphenolic substances in cacao liquor
N. Osakabe, M. Yamagishi, M. Natsume, T. Takizawa, T. Nakamura, T. Osawa
 ACS Symposium Series 754巻 88から 101ページまで Oxford University Press
2000/01 Effects of Cacao Liquor Polyphenols on the Susceptibility of Low-density Lipoprotein to Oxidation in Hypercholesterolemic Rabbits
Naomi Osakabe, Midori Natsume, Toko Adachi, Megumi Yamagishi, Reiko Hirano, Toshio Takizawa, Hiroshige Itakura, Kazuo Kondo
 Journal of Atherosclerosis and Thrombosis 7巻 3号 164から 168ページまで Japan Atherosclerosis Society